Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra
Identifieur interne : 000928 ( Main/Corpus ); précédent : 000927; suivant : 000929Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra
Auteurs : Maher A. Noureddine ; Yi-Ju Li ; Joelle M. Van Der Walt ; Robert Walters ; Rita M. Jewett ; Hong Xu ; Tianyuan Wang ; Jeffrey W. Walter ; Burton L. Scott ; Christine Hulette ; Don Schmechel ; Judith E. Stenger ; Fred Dietrich ; Jeffery M. Vance ; Michael A. HauserSource :
- Movement Disorders [ 0885-3185 ] ; 2005-10.
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Abstract
Genomic convergence is a multistep approach that combines gene expression with genomic linkage to identify and prioritize susceptibility genes for complex disease. As a first step, we previously performed linkage analysis on 174 multiplex Parkinson's disease (PD) families, identifying five peaks for PD risk and two for genes affecting age at onset (AAO) in PD [Hauser et al., Hum Mol Genet 2003;12:671–677]. We report here the next step: serial analysis of gene expression [SAGE; Scott et al., JAMA 2001;286:2239–2242] to analyze substantia nigra tissue from three PD patients and two age‐matched controls. We find 933 differentially expressed genes (P < 0.05) between PD and controls, but of these, only 50 genes represented by unique SAGE tags map within our previously described PD linkage regions. Furthermore, genes encoded by mitochondrial DNA are expressed 1.5‐fold higher in PD patients versus controls, without an increase in the corresponding nuclear‐encoded mitochondrial components, suggesting an increase in mtDNA genomes in PD or a disjunction with nuclear expression. The next step in the genomic convergence process will be to screen these 50 high‐quality candidate genes for association with PD risk susceptibility and genetic effects on AAO. © 2005 Movement Disorder Society
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DOI: 10.1002/mds.20573
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Noureddine</name><affiliation><mods:affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Li, Yi U" sort="Li, Yi U" uniqKey="Li Y" first="Yi-Ju" last="Li">Yi-Ju Li</name><affiliation><mods:affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Van Der Walt, Joelle M" sort="Van Der Walt, Joelle M" uniqKey="Van Der Walt J" first="Joelle M." last="Van Der Walt">Joelle M. Van Der Walt</name><affiliation><mods:affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Walters, Robert" sort="Walters, Robert" uniqKey="Walters R" first="Robert" last="Walters">Robert Walters</name><affiliation><mods:affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Jewett, Rita M" sort="Jewett, Rita M" uniqKey="Jewett R" first="Rita M." last="Jewett">Rita M. Jewett</name><affiliation><mods:affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Xu, Hong" sort="Xu, Hong" uniqKey="Xu H" first="Hong" last="Xu">Hong Xu</name><affiliation><mods:affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Wang, Tianyuan" sort="Wang, Tianyuan" uniqKey="Wang T" first="Tianyuan" last="Wang">Tianyuan Wang</name><affiliation><mods:affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Walter, Jeffrey W" sort="Walter, Jeffrey W" uniqKey="Walter J" first="Jeffrey W." last="Walter">Jeffrey W. Walter</name><affiliation><mods:affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Scott, Burton L" sort="Scott, Burton L" uniqKey="Scott B" first="Burton L." last="Scott">Burton L. Scott</name><affiliation><mods:affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medicine, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Hulette, Christine" sort="Hulette, Christine" uniqKey="Hulette C" first="Christine" last="Hulette">Christine Hulette</name><affiliation><mods:affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pathology, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Schmechel, Don" sort="Schmechel, Don" uniqKey="Schmechel D" first="Don" last="Schmechel">Don Schmechel</name><affiliation><mods:affiliation>Department of Medicine, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Stenger, Judith E" sort="Stenger, Judith E" uniqKey="Stenger J" first="Judith E." last="Stenger">Judith E. Stenger</name><affiliation><mods:affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Dietrich, Fred" sort="Dietrich, Fred" uniqKey="Dietrich F" first="Fred" last="Dietrich">Fred Dietrich</name><affiliation><mods:affiliation>Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Vance, Jeffery M" sort="Vance, Jeffery M" uniqKey="Vance J" first="Jeffery M." last="Vance">Jeffery M. Vance</name><affiliation><mods:affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A." last="Hauser">Michael A. Hauser</name><affiliation><mods:affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-10">2005-10</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1299">1299</biblScope><biblScope unit="page" to="1309">1309</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5074B50F5F664B19062B337DCDC8A5C8366CC5B0</idno><idno type="DOI">10.1002/mds.20573</idno><idno type="ArticleID">MDS20573</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>genomic convergence</term><term>linkage</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">Genomic convergence is a multistep approach that combines gene expression with genomic linkage to identify and prioritize susceptibility genes for complex disease. As a first step, we previously performed linkage analysis on 174 multiplex Parkinson's disease (PD) families, identifying five peaks for PD risk and two for genes affecting age at onset (AAO) in PD [Hauser et al., Hum Mol Genet 2003;12:671–677]. We report here the next step: serial analysis of gene expression [SAGE; Scott et al., JAMA 2001;286:2239–2242] to analyze substantia nigra tissue from three PD patients and two age‐matched controls. We find 933 differentially expressed genes (P < 0.05) between PD and controls, but of these, only 50 genes represented by unique SAGE tags map within our previously described PD linkage regions. Furthermore, genes encoded by mitochondrial DNA are expressed 1.5‐fold higher in PD patients versus controls, without an increase in the corresponding nuclear‐encoded mitochondrial components, suggesting an increase in mtDNA genomes in PD or a disjunction with nuclear expression. The next step in the genomic convergence process will be to screen these 50 high‐quality candidate genes for association with PD risk susceptibility and genetic effects on AAO. © 2005 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Maher A. Noureddine PhD</name><affiliations><json:string>Center for Human Genetics, Duke University, Durham, North Carolina, USA</json:string><json:string>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</json:string></affiliations></json:item><json:item><name>Yi‐Ju Li PhD</name><affiliations><json:string>Center for Human Genetics, Duke University, Durham, North Carolina, USA</json:string><json:string>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</json:string></affiliations></json:item><json:item><name>Joelle M. van der Walt PhD</name><affiliations><json:string>Center for Human Genetics, Duke University, Durham, North Carolina, USA</json:string><json:string>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</json:string></affiliations></json:item><json:item><name>Robert Walters BA</name><affiliations><json:string>Center for Human Genetics, Duke University, Durham, North Carolina, USA</json:string><json:string>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</json:string></affiliations></json:item><json:item><name>Rita M. Jewett RN</name><affiliations><json:string>Center for Human Genetics, Duke University, Durham, North Carolina, USA</json:string><json:string>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</json:string></affiliations></json:item><json:item><name>Hong Xu MS</name><affiliations><json:string>Center for Human Genetics, Duke University, Durham, North Carolina, USA</json:string></affiliations></json:item><json:item><name>Tianyuan Wang MS</name><affiliations><json:string>Center for Human Genetics, Duke University, Durham, North Carolina, USA</json:string><json:string>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</json:string></affiliations></json:item><json:item><name>Jeffrey W. Walter PhD</name><affiliations><json:string>Center for Human Genetics, Duke University, Durham, North Carolina, USA</json:string><json:string>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</json:string></affiliations></json:item><json:item><name>Burton L. Scott MD</name><affiliations><json:string>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</json:string><json:string>Department of Medicine, Duke University, Durham, North Carolina, USA</json:string></affiliations></json:item><json:item><name>Christine Hulette MD</name><affiliations><json:string>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</json:string><json:string>Department of Pathology, Duke University, Durham, North Carolina, USA</json:string><json:string>Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, North Carolina, USA</json:string></affiliations></json:item><json:item><name>Don Schmechel MD</name><affiliations><json:string>Department of Medicine, Duke University, Durham, North Carolina, USA</json:string><json:string>Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, North Carolina, USA</json:string></affiliations></json:item><json:item><name>Judith E. Stenger PhD</name><affiliations><json:string>Center for Human Genetics, Duke University, Durham, North Carolina, USA</json:string></affiliations></json:item><json:item><name>Fred Dietrich PhD</name><affiliations><json:string>Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA</json:string></affiliations></json:item><json:item><name>Jeffery M. Vance MD, PhD</name><affiliations><json:string>Center for Human Genetics, Duke University, Durham, North Carolina, USA</json:string><json:string>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</json:string></affiliations></json:item><json:item><name>Michael A. Hauser PhD</name><affiliations><json:string>Center for Human Genetics, Duke University, Durham, North Carolina, USA</json:string><json:string>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>linkage</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genomic convergence</value></json:item></subject><articleId><json:string>MDS20573</json:string></articleId><language><json:string>eng</json:string></language><abstract>Genomic convergence is a multistep approach that combines gene expression with genomic linkage to identify and prioritize susceptibility genes for complex disease. As a first step, we previously performed linkage analysis on 174 multiplex Parkinson's disease (PD) families, identifying five peaks for PD risk and two for genes affecting age at onset (AAO) in PD [Hauser et al., Hum Mol Genet 2003;12:671–677]. We report here the next step: serial analysis of gene expression [SAGE; Scott et al., JAMA 2001;286:2239–2242] to analyze substantia nigra tissue from three PD patients and two age‐matched controls. We find 933 differentially expressed genes (P > 0.05) between PD and controls, but of these, only 50 genes represented by unique SAGE tags map within our previously described PD linkage regions. Furthermore, genes encoded by mitochondrial DNA are expressed 1.5‐fold higher in PD patients versus controls, without an increase in the corresponding nuclear‐encoded mitochondrial components, suggesting an increase in mtDNA genomes in PD or a disjunction with nuclear expression. The next step in the genomic convergence process will be to screen these 50 high‐quality candidate genes for association with PD risk susceptibility and genetic effects on AAO. © 2005 Movement Disorder Society</abstract><qualityIndicators><score>7.34</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>3</keywordCount><abstractCharCount>1294</abstractCharCount><pdfWordCount>5821</pdfWordCount><pdfCharCount>40837</pdfCharCount><pdfPageCount>11</pdfPageCount><abstractWordCount>195</abstractWordCount></qualityIndicators><title>Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia 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nigra</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2005</date></publicationStmt><notesStmt><note>National Institutes of Health - No. NS39764; No. ES00372; No. P50 AG05128;</note><note>Postdoctoral Fellowship from the APDA</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra</title><author><persName><forename type="first">Maher A.</forename><surname>Noureddine</surname></persName><roleName type="degree">PhD</roleName><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</affiliation></author><author><persName><forename type="first">Yi‐Ju</forename><surname>Li</surname></persName><roleName type="degree">PhD</roleName><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</affiliation></author><author><persName><forename type="first">Joelle M.</forename><surname>van der Walt</surname></persName><roleName type="degree">PhD</roleName><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</affiliation></author><author><persName><forename type="first">Robert</forename><surname>Walters</surname></persName><roleName type="degree">BA</roleName><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</affiliation></author><author><persName><forename type="first">Rita M.</forename><surname>Jewett</surname></persName><roleName type="degree">RN</roleName><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</affiliation></author><author><persName><forename type="first">Hong</forename><surname>Xu</surname></persName><roleName type="degree">MS</roleName><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation></author><author><persName><forename type="first">Tianyuan</forename><surname>Wang</surname></persName><roleName type="degree">MS</roleName><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</affiliation></author><author><persName><forename type="first">Jeffrey 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Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, North Carolina, USA</affiliation></author><author><persName><forename type="first">Don</forename><surname>Schmechel</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Medicine, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, North Carolina, USA</affiliation></author><author><persName><forename type="first">Judith E.</forename><surname>Stenger</surname></persName><roleName type="degree">PhD</roleName><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation></author><author><persName><forename type="first">Fred</forename><surname>Dietrich</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, 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As a first step, we previously performed linkage analysis on 174 multiplex Parkinson's disease (PD) families, identifying five peaks for PD risk and two for genes affecting age at onset (AAO) in PD [Hauser et al., Hum Mol Genet 2003;12:671–677]. We report here the next step: serial analysis of gene expression [SAGE; Scott et al., JAMA 2001;286:2239–2242] to analyze substantia nigra tissue from three PD patients and two age‐matched controls. We find 933 differentially expressed genes (P < 0.05) between PD and controls, but of these, only 50 genes represented by unique SAGE tags map within our previously described PD linkage regions. Furthermore, genes encoded by mitochondrial DNA are expressed 1.5‐fold higher in PD patients versus controls, without an increase in the corresponding nuclear‐encoded mitochondrial components, suggesting an increase in mtDNA genomes in PD or a disjunction with nuclear expression. The next step in the genomic convergence process will be to screen these 50 high‐quality candidate genes for association with PD risk susceptibility and genetic effects on AAO. © 2005 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>linkage</term></item><item><term>genomic convergence</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2004-12-15">Received</change><change when="2005-01-31">Registration</change><change when="2005-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/5074B50F5F664B19062B337DCDC8A5C8366CC5B0/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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As a first step, we previously performed linkage analysis on 174 multiplex Parkinson's disease (PD) families, identifying five peaks for PD risk and two for genes affecting age at onset (AAO) in PD [Hauser et al., Hum Mol Genet 2003;12:671–677]. We report here the next step: serial analysis of gene expression [SAGE; Scott et al., JAMA 2001;286:2239–2242] to analyze substantia nigra tissue from three PD patients and two age‐matched controls. We find 933 differentially expressed genes (<i>P</i> < 0.05) between PD and controls, but of these, only 50 genes represented by unique SAGE tags map within our previously described PD linkage regions. Furthermore, genes encoded by mitochondrial DNA are expressed 1.5‐fold higher in PD patients versus controls, without an increase in the corresponding nuclear‐encoded mitochondrial components, suggesting an increase in mtDNA genomes in PD or a disjunction with nuclear expression. The next step in the genomic convergence process will be to screen these 50 high‐quality candidate genes for association with PD risk susceptibility and genetic effects on AAO. © 2005 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>SAGE Analysis of the Substantia Nigra</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra</title></titleInfo><name type="personal"><namePart type="given">Maher A.</namePart><namePart type="family">Noureddine</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yi‐Ju</namePart><namePart type="family">Li</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joelle M.</namePart><namePart type="family">van der Walt</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert</namePart><namePart type="family">Walters</namePart><namePart type="termsOfAddress">BA</namePart><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rita M.</namePart><namePart type="family">Jewett</namePart><namePart type="termsOfAddress">RN</namePart><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hong</namePart><namePart type="family">Xu</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tianyuan</namePart><namePart type="family">Wang</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jeffrey W.</namePart><namePart type="family">Walter</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Burton L.</namePart><namePart type="family">Scott</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Department of Medicine, Duke University, Durham, North Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christine</namePart><namePart type="family">Hulette</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Department of Pathology, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, North Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Don</namePart><namePart type="family">Schmechel</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Medicine, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, North Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Judith E.</namePart><namePart type="family">Stenger</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fred</namePart><namePart type="family">Dietrich</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jeffery M.</namePart><namePart type="family">Vance</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael A.</namePart><namePart type="family">Hauser</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Center for Human Genetics, Duke University, Durham, North Carolina, USA</affiliation><affiliation>Duke Udall Center of Excellence, Duke University, Durham, North Carolina, USA</affiliation><description>Correspondence: Center for Human Genetics, Duke University Medical Center, DUMC, Box 2903, Durham, NC 27710‐2903</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2005-10</dateIssued><dateCaptured encoding="w3cdtf">2004-12-15</dateCaptured><dateValid encoding="w3cdtf">2005-01-31</dateValid><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">6</extent><extent unit="references">64</extent><extent unit="words">7557</extent></physicalDescription><abstract lang="fr">Genomic convergence is a multistep approach that combines gene expression with genomic linkage to identify and prioritize susceptibility genes for complex disease. As a first step, we previously performed linkage analysis on 174 multiplex Parkinson's disease (PD) families, identifying five peaks for PD risk and two for genes affecting age at onset (AAO) in PD [Hauser et al., Hum Mol Genet 2003;12:671–677]. We report here the next step: serial analysis of gene expression [SAGE; Scott et al., JAMA 2001;286:2239–2242] to analyze substantia nigra tissue from three PD patients and two age‐matched controls. We find 933 differentially expressed genes (P < 0.05) between PD and controls, but of these, only 50 genes represented by unique SAGE tags map within our previously described PD linkage regions. Furthermore, genes encoded by mitochondrial DNA are expressed 1.5‐fold higher in PD patients versus controls, without an increase in the corresponding nuclear‐encoded mitochondrial components, suggesting an increase in mtDNA genomes in PD or a disjunction with nuclear expression. The next step in the genomic convergence process will be to screen these 50 high‐quality candidate genes for association with PD risk susceptibility and genetic effects on AAO. © 2005 Movement Disorder Society</abstract><note type="funding">National Institutes of Health - No. NS39764; No. ES00372; No. P50 AG05128; </note><note type="funding">Postdoctoral Fellowship from the APDA</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>linkage</topic><topic>genomic convergence</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1299</start><end>1309</end><total>11</total></extent></part></relatedItem><identifier type="istex">5074B50F5F664B19062B337DCDC8A5C8366CC5B0</identifier><identifier type="DOI">10.1002/mds.20573</identifier><identifier type="ArticleID">MDS20573</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2005 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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